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Nek2 inhibitor 3a
CAS No. ——
Nek2 inhibitor 3a( —— )
Catalog No. M17081 CAS No. ——
A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNek2 inhibitor 3a
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
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DescriptionA potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays; inhibits only 3 kinases (YSK4, FLT3-ITDD835V and FLT3-ITDF691L) against 97 kinases with >65% inhibition at 15 nM; blocks NEK2-EZH2 complex formation and inhibits tumor cell proliferation; efficiently attenuates GBM growth in mouse model and exhibits a synergistic effect with radiotherapy.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHec1/Nek2
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RecptorHec1/Nek2
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight568.619
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Molecular FormulaC28H27F3N6O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-5-(7-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang J, et al. J Clin Invest. 2017 Aug 1;127(8):3075-3089.
molnova catalog
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