Nek2 inhibitor 3a

CAS No. ——

Nek2 inhibitor 3a( —— )

Catalog No. M17081 CAS No. ——

A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Nek2 inhibitor 3a
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays.
  • Description
    A potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays; inhibits only 3 kinases (YSK4, FLT3-ITDD835V and FLT3-ITDF691L) against 97 kinases with >65% inhibition at 15 nM; blocks NEK2-EZH2 complex formation and inhibits tumor cell proliferation; efficiently attenuates GBM growth in mouse model and exhibits a synergistic effect with radiotherapy.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Hec1/Nek2
  • Recptor
    Hec1/Nek2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    568.619
  • Molecular Formula
    C28H27F3N6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (R)-5-(7-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang J, et al. J Clin Invest. 2017 Aug 1;127(8):3075-3089.
molnova catalog
related products
  • INH154

    INH154?is a novel small molecules disrupting Hec1/Nek2 interaction.

  • Nek2 inhibitor 72

    A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM.

  • TAI-95

    TAI-95 (TAI 95)?is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum.